Dry eye is probably the most common condition that is seen in eye clnics though not always the chief complaint. Important points about dry eye are that we adapt to dryness over time so become desensitized to it. This is worsened in patients who are diabetic and prone to neuropathies that will diminish corneal sensitivity. Dry eye is worse as we get older due to hormonal changes as well as loss of our protective mucin layer. This is accelerated with frequent irritation that includes direct sun, wind and dust, and allergens. Other factors that have an impact on dry eye are the use of eye drop medications such as those used to treat glaucoma. Systemic medications can also result in decreased tear production that worsens dry eye. All of these factors combined with the widespread use of screens on cell phones and computer displays has led to dry eyes being an epidemic. TREATMENT- Dry eye treatment typically begins with use of topical drops or artificial tears which improve wetting but do little to address root cause. These provide momentary symptomatic relief but little more. Immunomodulators and anti-inflammatory medications can address low grade inflammation and over time improve the ocular surface to restore components of the ocular surface. Improving function of the lipid producing meibomian glands using hot compresses can also be helpful. LATEST TREATMENT - Recently there has been pioneering work in the use of human amniotic membrane tissue to reinvigorate the ocular surface and stimulate corneal epithelial cell and corneal nerve regeneration. We have applied this breakthrough treatment to patients who continued to suffer symptoms of dry eye despite multiple treatments of other types.