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Thyroid Eye Disease

Risk Factors
Graves’ disease/hyperthyroidism (most common association)
Hypothyroidism (less common association)
Euthyroid thyroid eye disease (rare, normal thyroid levels)
Smoking (strongest modifiable risk factor; also linked to worse severity)
Prior radioiodine (RAI) therapy for hyperthyroidism can worsen or trigger TED in some patients
Family history of autoimmune thyroid disease
Symptoms
Bulging eyes (proptosis)
Dry, gritty, or irritated eyes
Redness and swelling around the eyes
Watery eyes or excessive tearing
Eyelid retraction (upper eyelids pulled back)
Double vision (diplopia)
Blurred or reduced vision
Pain or pressure in and around the eyes
Sensitivity to light (photophobia)
Difficulty moving the eyes
Swelling of eyelids or tissues around the eyes
In severe cases, vision loss due to optic nerve compression
reatment of thyroid eye disease is individualized and typically addresses four main areas: the ocular surface (dryness/irritation), ocular muscle function (double vision), inflammation of orbital tissues, and appearance/proptosis. Traditional measures often begin with surface lubrication and supportive care, and in more advanced cases may include surgical approaches such as orbital decompression to create more space in the orbit and relieve pressure.
However, surgery does not directly treat the underlying driver of the disease—inflammation of the orbital tissues and extraocular muscles. A major advance in treatment is Tepezza (teprotumumab), the first FDA-approved non-surgical medication for thyroid eye disease. Tepezza is an immunologic therapy designed to address the inflammatory process and has been shown to improve symptoms such as double vision, eye irritation, pain, and soft-tissue swelling in eligible patients.
Because all treatments have potential side effects and not every patient is a candidate, the best approach is determined based on disease activity, severity, and patient-specific factors. When surgery is still needed, it may be performed after medical therapy, and outcomes can be improved when inflammation is better controlled.